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Related Experiment Videos

Development of the human putamen: a morphometric study.

Y Nakae1, N Goto, T Nara

  • 1Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan.

Acta Anatomica
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

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Human fetal putamen development shows continuous neuronal migration until 33 weeks gestation. Neuronal numbers increase significantly post-33 weeks, with large neurons appearing around 30 weeks.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Human Anatomy

Background:

  • The human putamen is a crucial basal ganglia structure involved in motor control.
  • Understanding its developmental trajectory is essential for identifying potential neurodevelopmental disorders.

Purpose of the Study:

  • To investigate the developmental timeline of the human putamen.
  • To quantify neuronal proliferation, migration, and differentiation during fetal development.

Main Methods:

  • Analysis of complete serial sections from 6 human fetal brains.
  • Morphometric analysis of putaminal neurons across gestational ages (21-34 weeks).

Main Results:

  • Putaminal neuron number gradually increased from 21 to 33 weeks of gestation (WG).

Related Experiment Videos

  • Neuronal migration appears to continue until at least 33 WG, with a marked increase post-33 WG.
  • Large neurons (4-5 times the area of small neurons) emerged from 30 WG, comprising up to 1.4% of total neurons by 33-34 WG.
  • No significant neuronal death was observed between 21 and 34 WG.

    • Conclusions:

    • The human putamen undergoes significant neuronal addition and differentiation during late fetal development.
    • Neuronal migration and the emergence of distinct neuronal size classes are key features of human putamen development.