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Motilin and infantile colic. A prospective study.
L Lothe1, S A Ivarsson, R Ekman
1Department of Pediatrics, University of Lund, Malmö General Hospital, Sweden.
Acta Paediatrica Scandinavica
|April 1, 1990
Summary
Elevated S-motilin levels in infants with colic suggest gastrointestinal changes occur before symptoms appear. This finding offers early insights into infantile colic development.
Area of Science:
- Gastroenterology
- Neonatology
- Pediatric Research
Background:
- Infantile colic affects approximately 17.4% of infants.
- The exact causes of infantile colic remain incompletely understood.
- Early identification of contributing factors is crucial for infant well-being.
Purpose of the Study:
- To investigate the role of S-motilin in the development of infantile colic.
- To determine if elevated S-motilin levels precede the onset of colic symptoms.
- To compare S-motilin levels in formula-fed and breast-fed infants with and without colic.
Main Methods:
- Prospective study of 219 infants from birth to 12 weeks.
- S-motilin levels measured in 78 infants (19 with colic, 59 without) at birth, 1 day, 6 weeks, and 12 weeks.
- Comparison of S-motilin levels between infants with and without colic, stratified by feeding type.
Main Results:
- Infants who developed colic showed significantly higher S-motilin levels in cord blood and at 1 day, 6 weeks, and 12 weeks of age.
- Both formula-fed and breast-fed infants with colic exhibited higher basal motilin levels compared to controls at specific time points.
- Elevated S-motilin was observed from the first day of life in infants who later developed colic.
Conclusions:
- Raised S-motilin levels from birth may indicate early gastrointestinal alterations in infants who develop colic.
- Motilin's role warrants further investigation as a potential early biomarker for infantile colic.
- These findings suggest a potential biological basis for colic appearing very early in infancy.