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Related Experiment Video

Updated: May 13, 2026

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation
04:42

Treating Low Back Pain in Failed Back Surgery Patients with Multicolumn-lead Spinal Cord Stimulation

Published on: June 26, 2018

Default mode network functional connectivity altered in failed back surgery syndrome.

Jennifer Kornelsen1, Uta Sboto-Frankenstein, Theresa McIver

  • 1Magnetic Resonance Technology, Institute for Biodiagnostics, National Research Council Canada, Winnipeg, Canada. jennifer.kornelsen@nrc-cnrc.gc.ca

The Journal of Pain
|March 19, 2013
PubMed
Summary

Failed back surgery syndrome patients exhibit altered brain connectivity in the default mode network. This study reveals reduced connectivity and recruitment of pain-related brain regions in these patients compared to healthy individuals.

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Published on: July 1, 2014

Area of Science:

  • Neuroscience
  • Medical Imaging
  • Pain Research

Background:

  • Failed back surgery syndrome (FBSS) is a debilitating condition characterized by chronic pain after spinal surgery.
  • Understanding the neural underpinnings of FBSS is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate alterations in the default mode network (DMN) in patients with FBSS.
  • To compare DMN functional connectivity between FBSS patients and healthy controls.

Main Methods:

  • Resting-state functional magnetic resonance imaging (fMRI) at 3 Tesla.
  • Analysis of fMRI data using independent component analysis (ICA).

Main Results:

  • FBSS patients showed reduced functional connectivity within the DMN.
  • Recruitment of additional brain regions involved in pain modulation (e.g., dorsolateral prefrontal cortex, insula) was observed.
  • Activation of sensory-motor integration areas (precentral and postcentral gyri) was also noted in FBSS patients.

Conclusions:

  • FBSS is associated with significant alterations in DMN functional connectivity.
  • These alterations involve both decreased connectivity within the DMN and increased engagement of pain-processing and sensory-motor brain regions.