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High-throughput Screening for Protein-based Inheritance in S. cerevisiae
08:12

High-throughput Screening for Protein-based Inheritance in S. cerevisiae

Published on: August 8, 2017

Viruses and prions of Saccharomyces cerevisiae

Reed B Wickner1, Tsutomu Fujimura, Rosa Esteban

  • 1Laboratory of Biochemistry and Genetics, National Institute of Diabetes Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. wickner@helix.nih.gov

Advances in Virus Research
|March 19, 2013
PubMed

Insights

Saccharomyces cerevisiae serves as a vital model for studying infectious agents like viruses and prions. Research in yeast reveals how cellular components interact with and control these infectious elements.

Area of Science:

  • Microbiology
  • Virology
  • Prion Biology

Background:

  • * Saccharomyces cerevisiae is a crucial model organism for investigating infectious diseases.
  • * Yeast has been instrumental in understanding virus and prion replication mechanisms.
  • * Studies focus on virus structure and the amyloid filaments of yeast prions.

Purpose of the Study:

  • * To highlight the utility of yeast in studying infectious agents.
  • * To detail the interactions between yeast cellular components and infectious elements.
  • * To review specific infectious entities in yeast, including viruses and prions.

Main Methods:

  • * Review of existing literature on yeast as a model for infectious diseases.
  • * Analysis of studies on viral replication, structure, and prion formation in yeast.
  • * Examination of cellular components that regulate virus and prion propagation.

Main Results:

  • * Yeast facilitates research into double-stranded RNA (dsRNA) viruses, single-stranded RNA (ssRNA) viruses, and prions.
  • * Key findings include understanding virus/prion replication, structure, and cellular interactions.
  • * Identification of chromosomally encoded proteins that inhibit infectious agent propagation.

Conclusions:

  • * Saccharomyces cerevisiae is an indispensable model for infectious disease research.
  • * Yeast research has significantly advanced the understanding of viral and prion biology.
  • * Cellular interactions are critical for controlling infectious elements within yeast.

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