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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA (lncRNA)...
Types of RNA01:20

Types of RNA

Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
Types of RNA01:23

Types of RNA

Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
Non-LTR Retrotransposons03:18

Non-LTR Retrotransposons

As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...

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Related Experiment Video

Updated: May 13, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

Long noncoding RNAs: cellular address codes in development and disease.

Pedro J Batista1, Howard Y Chang

  • 1Howard Hughes Medical Institute and Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Cell
|March 19, 2013
PubMed
Summary
This summary is machine-generated.

Long noncoding RNAs (lncRNAs) act as a cellular address code, guiding molecules and genes to their correct locations. This precise nuclear organization is crucial for cell development and preventing diseases linked to genetic abnormalities.

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Related Experiment Videos

Last Updated: May 13, 2026

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA
09:36

RNA Pull-down Procedure to Identify RNA Targets of a Long Non-coding RNA

Published on: April 10, 2018

Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
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Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells

Published on: May 30, 2025

Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • Nuclear organization is fundamental to biological processes, akin to location in real estate.
  • Understanding the 'address code' for molecular and genetic elements within the nucleus is a key research question.
  • Long noncoding RNAs (lncRNAs) are increasingly recognized for their role in cellular organization.

Purpose of the Study:

  • To elucidate the role of lncRNAs as components of the nuclear address code.
  • To investigate how lncRNAs facilitate the trafficking and regulation of cellular components.
  • To explore the implications of lncRNA function in development and disease.

Main Methods:

  • The study focuses on the functional mechanisms of lncRNAs in nuclear organization.
  • Investigates how lncRNAs mediate the localization of protein complexes, genes, and chromosomes.
  • Examines the link between lncRNA dysregulation and chromosomal abnormalities.

Main Results:

  • lncRNAs serve as critical elements in the nuclear address code.
  • These molecules direct the proper placement and retrieval of cellular components.
  • lncRNA-based mechanisms are essential for controlling cell fates during development.
  • Dysregulation of lncRNAs is implicated in human disorders involving chromosomal alterations.

Conclusions:

  • lncRNAs are key regulators of nuclear organization and cellular function.
  • Their role in trafficking and localization is vital for normal development.
  • Aberrant lncRNA activity contributes to genetic disorders and diseases.