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High-throughput Synthesis of Carbohydrates and Functionalization of Polyanhydride Nanoparticles
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Phase transfer-catalyzed synthesis of highly acrylated hyaluronan

Jana Becher1, Stephanie Möller, Matthias Schnabelrauch

  • 1INNOVENT e.V., Biomaterials Department, Prüssingstr. 27B, D-07745 Jena, Germany.

Carbohydrate Polymers
|March 19, 2013
PubMed

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As shown below, the mechanism involves a nucleophilic attack by water at the carbonyl carbon to form a tetrahedral intermediate. This is followed by the reformation of the carbon–oxygen π bond along with the departure of a halide ion. A final proton transfer step yields carboxylic acid...
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