Related Experiment Video
Updated: May 13, 2026

Stromal Cell Isolation From Hematopoietic Organs
Published on: January 26, 2024
Bone marrow cells as precursors of the tumor stroma
Daniel L Worthley1, Yiling Si1, Michael Quante2
1Department of Medicine, Columbia University, NY, USA.
Abstract:
Cancer is a systemic disease. Local and distant factors conspire to promote or inhibit tumorigenesis. The bone marrow is one important source of tumor promoting cells. These include the important mature and immature hematopoietic cells as well as circulating mesenchymal progenitors. Recruited bone marrow cells influence carcinogenesis at the primary site, within the lymphoreticular system and even presage metastasis through their recruitment to distant organs. In this review we focus on the origins and contribution of cancer-associated fibroblasts in tumorigenesis. Mesenchymal cells present an important opportunity for targeted cancer prevention and therapy.
Related Concept Videos
The Tumor Microenvironment
Stem Cell Therapy for Tissue Regeneration
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Production of Formed Elements
Most HSCs commit to...
Cancer Stem Cells and Tumor Maintenance
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
Hematopoiesis

