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Related Experiment Videos

Periappendicitis is a significant clinical finding.

A S Fink1, C A Kosakowski, J R Hiatt

  • 1Department of Surgery, University of Cincinnati Medical Center, Ohio 45267-0558.

American Journal of Surgery
|June 1, 1990
PubMed
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Periappendicitis, inflammation of the appendix outer layer, is often overlooked. This study reveals it has significant clinical implications, with a high complication rate in patients initially suspected of acute appendicitis.

Area of Science:

  • Medicine
  • Pathology
  • Surgery

Background:

  • Periappendicitis, inflammation of the serosal layer of the appendix, has historically been considered a minor pathological finding.
  • Its clinical significance has been largely underestimated in medical literature.

Purpose of the Study:

  • To evaluate the clinical significance and outcomes of periappendicitis.
  • To determine the incidence and complications associated with periappendicitis in patients undergoing appendectomy.

Main Methods:

  • Retrospective review of appendectomy specimens at UCLA between 1955 and 1985.
  • Analysis of 353 cases with pathologically confirmed periappendicitis, focusing on a subgroup of 41 patients initially suspected of acute appendicitis.

Main Results:

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  • Of 353 patients with periappendicitis, 41 were initially suspected of acute appendicitis but had only periappendicitis on examination.
  • This group (9 males, 32 females, mean age 29) experienced a 44% complication rate (24 complications in 18 patients).
  • Five patients (12%) required additional surgery, and one patient (2%) died.

Conclusions:

  • Periappendicitis is not merely a pathological curiosity and carries significant clinical implications.
  • Patients presenting with symptoms suggestive of acute appendicitis but found to have periappendicitis require careful management due to potential complications.
  • Further clinical investigation into periappendicitis is warranted.