Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Muscles of the Forearm that Move the Hand and Fingers01:16

Muscles of the Forearm that Move the Hand and Fingers

The muscles of the forearm that move the wrist, hand, and digits are numerous and diverse. They can be classified into two groups based on their location and function — the anterior and posterior compartment muscles.
Anterior Compartment
The anterior compartment muscles originate from the humerus. They primarily function as flexors and are also known as flexor muscles. They typically insert on the carpals, metacarpals, and phalanges. The superficial layer includes the flexor carpi radialis,...
Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prevalence and Relative Proportions of MS, NMOSD, and MOGAD in the Republic of Korea.

Neurology·2026
Same author

Functional ability in cognitive complaints: The role of neuropsychiatric and cognitive factors in community-dwelling older adults.

Alzheimer's & dementia. Behavior & socioeconomics of aging·2026
Same author

Protein C Activity and Atrial Fibrillation-Related Thrombogenic Phenotypes in Patients With Ischemic Stroke.

American journal of hematology·2026
Same author

Prevalence and Relative Proportions of Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorder, and Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease in the Republic of Korea.

Neurology·2026
Same author

The One-and-a-Half Syndrome of Korean Clinical Training: 1.5 Years of Fracturing.

Journal of clinical neurology (Seoul, Korea)·2026
Same author

Ipsilateral Pseudochoreoathetosis and Numbness Can Be a Sole Manifestation of Lateral Medullary Infarction.

Journal of clinical neurology (Seoul, Korea)·2026

Related Experiment Video

Updated: May 13, 2026

Intact Short, Intermediate, and Long Skeletal Muscle Fibers Obtained by Enzymatic Dissociation of Six Hindlimb Muscles of Mice: Beyond Flexor Digitorum Brevis
08:12

Intact Short, Intermediate, and Long Skeletal Muscle Fibers Obtained by Enzymatic Dissociation of Six Hindlimb Muscles of Mice: Beyond Flexor Digitorum Brevis

Published on: December 1, 2023

Cortical excitability differences between flexor pollicis longus and APB.

Jong Seok Bae1, Parvathi Menon, Eneida Mioshi

  • 1Neuroscience Research Australia, Australia.

Neuroscience Letters
|March 19, 2013
PubMed
Summary
This summary is machine-generated.

Cortical excitability differs between the flexor pollicis longus (FPL) and abductor pollicis brevis (APB) muscles. Reduced cortical inhibition over the FPL may explain muscle atrophy in amyotrophic lateral sclerosis (ALS).

More Related Videos

In Vivo Electrophysiological Measurement of the Rat Ulnar Nerve with Axonal Excitability Testing
04:56

In Vivo Electrophysiological Measurement of the Rat Ulnar Nerve with Axonal Excitability Testing

Published on: February 6, 2018

Assessment of Neuromuscular Function Using Percutaneous Electrical Nerve Stimulation
07:53

Assessment of Neuromuscular Function Using Percutaneous Electrical Nerve Stimulation

Published on: September 13, 2015

Related Experiment Videos

Last Updated: May 13, 2026

Intact Short, Intermediate, and Long Skeletal Muscle Fibers Obtained by Enzymatic Dissociation of Six Hindlimb Muscles of Mice: Beyond Flexor Digitorum Brevis
08:12

Intact Short, Intermediate, and Long Skeletal Muscle Fibers Obtained by Enzymatic Dissociation of Six Hindlimb Muscles of Mice: Beyond Flexor Digitorum Brevis

Published on: December 1, 2023

In Vivo Electrophysiological Measurement of the Rat Ulnar Nerve with Axonal Excitability Testing
04:56

In Vivo Electrophysiological Measurement of the Rat Ulnar Nerve with Axonal Excitability Testing

Published on: February 6, 2018

Assessment of Neuromuscular Function Using Percutaneous Electrical Nerve Stimulation
07:53

Assessment of Neuromuscular Function Using Percutaneous Electrical Nerve Stimulation

Published on: September 13, 2015

Area of Science:

  • Neuroscience
  • Motor Control
  • Neurology

Background:

  • Abductor pollicis brevis (APB) and flexor pollicis longus (FPL) muscles have distinct functions despite shared nerve supply.
  • Functional differences may lead to varied effects in neurodegenerative diseases like amyotrophic lateral sclerosis (ALS).
  • Investigating cortical excitability differences could elucidate disease mechanisms.

Purpose of the Study:

  • To assess and compare cortical excitability between the APB and FPL muscles.
  • To explore potential differences in corticomotoneuronal output related to functional specialization.
  • To determine if these differences correlate with observed muscle atrophy patterns in ALS.

Main Methods:

  • Utilized threshold tracking transcranial magnetic stimulation (TMS) in 15 healthy controls.
  • Recorded motor responses over APB and FPL muscles using surface electrodes.
  • Measured short-interval intracortical inhibition (SICI) and cortical silent period (CSP).

Main Results:

  • Short-interval intracortical inhibition (SICI) was significantly reduced for FPL compared to APB (6.9% vs. 10.7%).
  • Motor evoked potential (MEP) amplitude was significantly smaller for FPL compared to APB (14.7% vs. 21.7%).
  • Cortical silent period (CSP) duration was significantly shorter for FPL compared to APB (174.7 ms vs. 205.4 ms).

Conclusions:

  • Cortical inhibition and corticomotoneuronal output are reduced when recording over the FPL muscle.
  • These excitability differences may arise from functional specialization.
  • Findings suggest a potential explanation for dissociated muscle atrophy observed in amyotrophic lateral sclerosis (ALS).