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Tardive dyskinesia treated with pimozide.

L E Claveria, P F Teychenne, D B Calne

    Journal of the Neurological Sciences
    |April 1, 1975
    PubMed
    Summary

    Pimozide effectively treated tardive dyskinesia in a study. This condition, caused by antipsychotics, showed improvement with pimozide, though side effects like parkinsonism occurred.

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    Area of Science:

    • Neuroscience
    • Pharmacology
    • Psychiatry

    Background:

    • Tardive dyskinesia (TD) is a movement disorder often resulting from long-term use of antipsychotic medications like phenothiazines.
    • The underlying pathophysiology of TD is thought to involve an imbalance of central neurotransmitters, particularly increased dopaminergic transmission.

    Purpose of the Study:

    • To evaluate the efficacy and safety of pimozide in treating tardive dyskinesia.
    • To investigate the therapeutic window and adverse effects of pimozide in patients with phenothiazine-induced TD.

    Main Methods:

    • A double-blind study was conducted involving 18 patients diagnosed with tardive dyskinesia.
    • Patients received pimozide at a maximum tolerated dosage (mean 18.8 mg/day) for a duration of 6 weeks.

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    Main Results:

    • Significant improvement in tardive dyskinesia symptoms was observed during the 6-week treatment period.
    • No decline in pimozide's therapeutic effect was noted over the study duration.
    • The primary adverse effects reported were parkinsonism and sedation, which were manageable through dose adjustments.

    Conclusions:

    • Pimozide demonstrates therapeutic potential in managing tardive dyskinesia.
    • The findings support the hypothesis that TD involves an imbalance in central neurotransmitter systems, specifically heightened dopaminergic activity.