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Investigation on the interaction behavior between curcumin and PAMAM dendrimer by spectral and docking studies
Jian Cao1, Hongmei Zhang, Yanqing Wang
1Institute of Applied Chemistry and Environmental Engineering, Yancheng Teachers University, Yancheng City, Jiangsu Province 224002, People's Republic of China. yctu_caojian@126.com
Abstract:
The interactions between PAMAM-C12 25% and curcumin were studied by UV/vis, fluorescence spectroscopy, and molecular modeling methods. The experimental results showed that the formation of PAMAM-C12 25%@curcumin non-covalent adduct induced the fluorescence quenching of PAMAM-C12 25%; Curcumin entered the interface of PAMAM-C12 25% with mainly five classes of binding sites by hydrophobic, hydrogen bonds, and van der Waals forces interactions. The bigger values of binding constants indicated that PAMAM-C12 25% hold the curcumin tightly.
