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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
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Cancer Survival Analysis

Cancer survival analysis focuses on quantifying and interpreting the time from a key starting point, such as diagnosis or the initiation of treatment, to a specific endpoint, such as remission or death. This analysis provides critical insights into treatment effectiveness and factors that influence patient outcomes, helping to shape clinical decisions and guide prognostic evaluations. A cornerstone of oncology research, survival analysis tackles the challenges of skewed, non-normally...
Treatment Resistant Cancers02:56

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

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As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...

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Updated: May 13, 2026

Laparoscopic Radical Gastrectomy for Remnant Gastric Cancer
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Published on: October 31, 2025

Comprehensive geriatric assessment in oncology.

Supriya G Mohile1, Allison Magnuson

  • 1School of Medicine and Dentistry, University of Rochester Medical Center, Rochester, NY 14642, USA. supriya_mohile@urmc.rochester.edu

Interdisciplinary Topics in Gerontology
|March 19, 2013
PubMed
Summary

Comprehensive Geriatric Assessment (CGA) helps oncologists evaluate older cancer patients. It predicts treatment tolerance and toxicity, guiding safer, more effective care for the geriatric population.

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Last Updated: May 13, 2026

Laparoscopic Radical Gastrectomy for Remnant Gastric Cancer
05:30

Laparoscopic Radical Gastrectomy for Remnant Gastric Cancer

Published on: October 31, 2025

Area of Science:

  • Geriatric Oncology
  • Clinical Geriatrics
  • Cancer Treatment

Background:

  • Cancer incidence and mortality rise significantly in patients aged 65 and older.
  • Chronological age alone is insufficient to assess the health status of geriatric patients.
  • Physiologic and functional capacity are crucial for safe and effective cancer treatment in older adults.

Purpose of the Study:

  • To review the components and predictive value of Comprehensive Geriatric Assessment (CGA) in older cancer patients.
  • To emphasize practical integration of CGA into clinical oncology practice.
  • To highlight the role of CGA in risk stratification for treatment tolerance and chemotherapy toxicity.

Main Methods:

  • Review of validated tools comprising the Comprehensive Geriatric Assessment (CGA).
  • Analysis of CGA's influence on clinical decision-making and outcomes in older cancer patients.
  • Discussion of screening tools for identifying patients who may benefit from further geriatric assessment.

Main Results:

  • CGA components predict morbidity and mortality in older adults.
  • CGA data can stratify cancer patients by risk for treatment tolerance and chemotherapy toxicity.
  • Screening tools can identify older cancer patients needing further comprehensive evaluation.

Conclusions:

  • Comprehensive Geriatric Assessment (CGA) is vital for optimizing cancer care in the geriatric population.
  • Integrating CGA and screening tools can improve treatment decisions and patient outcomes.
  • Practical application of CGA is essential for oncologists managing older cancer patients.