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Protein interaction discovery using parallel analysis of translated ORFs (PLATO)

Jian Zhu1,2,3, H Benjamin Larman1,4,5,2,3, Geng Gao1,2,3

  • 1Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Boston, MA.

Nature Biotechnology
|March 19, 2013
PubMed
Summary

We developed PLATO, a new method to map molecular interactions using ribosome display and DNA sequencing. This technique successfully identified known and novel interaction partners for human proteins and small molecules.

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