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Indications and pitfalls of immunohistochemistry in head and neck cancer
Décio de Natale Caly1, Acklei Viana, Abrão Rapoport
1Hospital Heliópolis, São Paulo, Brazil.
Unlabelled:
Immunohistochemistry (IHC) has been employed in the differential diagnosis of tumors.
Objective:
To assess the use of IHC in cases of head and neck tumor.
Method:
This is a retrospective study of the cases included in the Cancer Registry of the institution.
Results:
IHC was used in 76 (11%) of 704 pathology tests. Most cases were carcinomas (85.80%), and 83.66% of them were squamous cell carcinomas. All tests were done with diagnostic purposes. The most frequently used antibodies were 34BE12 (37.18%), AE1/AE3 (35.9%), 35BH11 (28.21%), CD45 (25.64%), CD20 (24.36%), CD30 (24.36%), CK7 (23.08%) and CD3 (23.08%).
Conclusions:
IHC was used in 10.67% of the head and neck tumor cases submitted to pathology testing, mostly for carcinoma (5.26%). In the determination of squamous cell carcinoma, IHC accounted for 18.42% of all tumors.
