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Published on: July 3, 2025
[Behcet's disease--ophthalmological and general aspects: Part 2: Therapy].
U Pleyer1, D Hazirolan, S Winterhalter
1Universitäts-Augenklinik, Uveitis Zentrum, Charité, Universitätsmedizin Berlin, Humboldt University, Augustenburger Platz 1, 13353, Berlin, Deutschland. uwe.pleyer@charite.de
Summary
Behcet's disease is a chronic vasculitis affecting multiple organs. Biologics like Interferon alpha and monoclonal antibodies offer new treatment options for severe ocular inflammation, improving outcomes for patients with Behcet's disease.
Area of Science:
- Rheumatology
- Ophthalmology
- Immunology
Context:
- Behcet's disease is a chronic, relapsing vasculitis with diverse organ involvement.
- Ocular manifestations can lead to severe vision loss, while systemic involvement poses life-threatening risks.
- Current treatments like Cyclosporin A have limitations due to toxicity.
Purpose:
- To review the current understanding of Behcet's disease management.
- To highlight the efficacy of biologic therapies in severe cases, particularly ocular inflammation.
- To emphasize the critical role of ophthalmologists in patient care.
Summary:
- Behcet's disease is a complex vasculitis with significant morbidity.
- Biologic agents, including Interferon alpha and monoclonal antibodies targeting TNF-alpha and interleukin-1, represent a therapeutic breakthrough for severe uveitis.
- These advanced therapies offer improved efficacy and potentially better safety profiles compared to conventional treatments.
Impact:
- Biologics have transformed the management of severe ocular Behcet's disease, offering hope for vision preservation.
- The findings underscore the need for multidisciplinary collaboration, with a key role for ophthalmologists.
- This review provides a concise overview for clinicians managing this challenging condition.
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