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Inhibition of AGEs formation by natural products

Ryoji Nagai1, Jun-Ichi Shirakawa, Rei-Ichi Ohno

  • 1Laboratory of Food and Regulation Biology Department of Bioscience, School of Agriculture, Tokai University, Kawayou Minamiaso Aso-gun, Kumamoto, 869-1404, Japan, nagai-883@umin.ac.jp.

Amino Acids
|March 19, 2013
PubMed

Insights

Advanced glycation end-products (AGEs) inhibitors show promise in preventing diabetic complications. Developing natural AGEs inhibitors from daily foods is a preferred strategy over prescribed drugs.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Preventive Medicine

Background:

  • Advanced glycation end-products (AGEs) contribute to lifestyle-related diseases, including diabetic complications and atherosclerosis.
  • Existing AGEs inhibitors like benfotiamine, pyridoxamine, and aminoguanidine have demonstrated efficacy in preclinical models.
  • Preventive medicine emphasizes nutritional strategies for disease pathogenesis.

Purpose of the Study:

  • To explore the potential of AGEs inhibitors in preventing lifestyle-related diseases.
  • To advocate for the development of AGEs inhibitors derived from natural sources for improved dietary integration.
  • To outline a strategy for discovering novel AGEs inhibitors from natural products.

Main Methods:

  • Review of existing literature on AGEs inhibitors and their effects.
  • Analysis of the role of nutritional intake in preventing AGEs-related pathogenesis.
  • Conceptual strategy for identifying natural product-based AGEs inhibitors.

Main Results:

  • AGEs inhibitors significantly inhibit the development of retinopathy and neuropathy in diabetic rat models.
  • Dietary AGEs inhibitors are considered a preferable approach compared to prescribed medications.
  • Natural products represent a viable source for developing new AGEs inhibitors.

Conclusions:

  • AGEs inhibitors are a promising therapeutic strategy for diabetic complications and atherosclerosis.
  • Focusing on naturally occurring AGEs inhibitors aligns with preventive medicine and nutritional improvement.
  • Further research into natural products can yield effective dietary AGEs inhibitors.

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