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Updated: May 13, 2026

Flow Cytometry-Based Quantification and Analysis of Myocardial B-Cells
Published on: August 17, 2022
Giant cell myocarditis associated with amoxicillin hypersensitivity reaction
Soledad Martinez1, Elvira Miranda, Patrick Kim
1Servicio Medico Legal, Av. La Paz 1012, Independencia, Santiago, Chile. soledadml@yahoo.com
Abstract:
We report a case of sudden unexpected death in an adult woman from florid myocarditis with necrosis, replacement fibrosis, and diffuse infiltration of the myocardium by eosinophils and conspicuous giant cells. Clinical history revealed that 3 weeks prior to death, shortly after commencing antibiotic therapy for the treatment of traumatic wound of a finger, she presented to the emergency room with a hypersensitivity reaction characterized by facial rash with edema and generalized pruritus. She was treated with antihistamines and discharged. The clinico-pathological correlation suggests a link between drug hypersensitivity and the giant cell myocarditis.
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