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Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

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Published on: June 3, 2020

Cohort profile: The Berlin Aging Study II (BASE-II).

Lars Bertram¹, Anke Böckenhoff¹, Ilja Demuth²

¹Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany, German Socio-Economic Panel Study (SOEP), Deutsches Institut für Wirtschaftsforschung, Berlin, Germany, Charité Research Group on Geriatrics, Charité-Universitätsmedizin, Berlin, Germany, Institute of Medical and Human Genetics, Charité-Universitätsmedizin, Berlin, Germany, Center for Lifespan Psychology, Max Planck Institute for Human Development, Berlin, Germany, Department of Psychology, TU Dresden, Dresden, Germany, Center for Medical Research, University of Tübingen, Tübingen, Germany, Department of Economics, University of Hamburg, Hamburg, Germany and Berlin University of Technology (TUB), Berlin, Germany.

International Journal of Epidemiology

|March 19, 2013

Summary

Germany

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Area of Science:

Gerontology and Geriatric Medicine
Population Health
Multidisciplinary Aging Research

Background:

Germany, like other industrialized nations, faces a significant population aging trend.
Aging is characterized by a spectrum from robust health to multiple age-related diseases, impacting lifespan and quality of life.
Understanding the determinants of healthy versus unhealthy aging is a critical public health challenge.

Purpose of the Study:

To identify and characterize factors distinguishing healthy from unhealthy aging.
To establish a comprehensive dataset on aging-related variables across diverse functional domains.
To facilitate collaborative research through data sharing.

Main Methods:

The Berlin Aging Study II (BASE-II) is a multidisciplinary, multi-institutional project.
Phenotypic assessments cover geriatrics, internal medicine, immunology, genetics, psychology, sociology, and economics.
Recruited 1600 older adults (60-80 years) and 600 younger adults (20-35 years) for baseline analysis; linked to German Socio-Economic Panel Study (SOEP) for sample selectivity.

Main Results:

Baseline recruitment of the BASE-II cohort is complete.
A large dataset of aging-related variables has been collected from a diverse cohort.
Data linkage with SOEP provides a framework for understanding sample representativeness.

Conclusions:

The BASE-II study has successfully established a comprehensive cohort for aging research in Germany.
The collected data will enable in-depth analyses of factors influencing healthy and unhealthy aging trajectories.
BASE-II is poised to advance scientific understanding and foster collaboration in the field of gerontology.