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Related Experiment Video

Updated: May 13, 2026

A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain

A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain

Published on: April 9, 2019

Brain: biomedical knowledge manipulation.

Samuel Croset¹, John P Overington, Dietrich Rebholz-Schuhmann

¹EMBL European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK. croset@ebi.ac.uk

Bioinformatics (Oxford, England)

|March 19, 2013

Summary

This summary is machine-generated.

Brain is a Java software library for creating and manipulating ontologies and knowledge bases using the Web Ontology Language (OWL). It is freely available with comprehensive documentation.

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Last Updated: May 13, 2026

A Human Blood-Brain Interface Model to Study Barrier Crossings by Pathogens or Medicines and Their Interactions with the Brain

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Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems

Published on: June 13, 2025

Area of Science:

Bioinformatics
Computer Science
Semantic Web Technologies

Background:

Ontologies and knowledge bases are crucial for organizing and reasoning over complex biological data.
The Web Ontology Language (OWL) is a standard for representing ontologies.
Existing tools may have limitations in flexibility or ease of use for ontology manipulation.

Purpose of the Study:

To introduce Brain, a novel Java software library.
To provide a flexible and efficient tool for ontology and knowledge base creation and manipulation.
To support the use of the Web Ontology Language (OWL) in bioinformatics and related fields.

Main Methods:

Development of a Java software library named Brain.
Implementation of functionalities for manipulating and creating ontologies.
Adherence to Web Ontology Language (OWL) standards for knowledge representation.

Main Results:

Brain facilitates the manipulation and creation of ontologies.
The library supports knowledge bases represented in OWL.
The software is designed for ease of integration into existing Java projects.

Conclusions:

Brain offers a robust solution for ontology engineering in Java.
The library enhances the development and management of OWL-based knowledge bases.
Brain is a valuable resource for researchers and developers working with semantic web technologies.