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Published on: January 28, 2020

Correlation between serum adiponectin and risk factors in patients with coronary artery disease

Suxin Luo1, Han Lei, Qing Liu

  • 1Department of Cardiology, First Affiliated Hospital, Chongqing Medical University, Chongqing 400016, China.

Clinical Laboratory
|March 20, 2013
PubMed

Insights

Serum adiponectin (ADP) levels are lower in patients with acute coronary syndrome, correlating negatively with high sensitivity C-reactive protein (hsCRP) and cardiovascular risk factors.

Area of Science:

  • Cardiovascular Medicine
  • Biochemistry

Background:

  • Coronary artery disease (CAD) is a significant health concern.
  • Understanding biomarkers like adiponectin (ADP) and high sensitivity C-reactive protein (hsCRP) is crucial for CAD management.

Purpose of the Study:

  • To investigate the correlation between serum adiponectin (ADP) and high sensitivity C-reactive protein (hsCRP).
  • To assess the relationship between these biomarkers and cardiovascular risk factors in patients with coronary artery disease (CAD).

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) was used to measure serum ADP.
  • Immunoturbidimetry was employed to quantify hsCRP levels.
  • 90 CAD patients (41 acute myocardial infarction, 27 unstable angina pectoris, 22 stable angina pectoris) and 20 healthy controls were studied.

Main Results:

  • Serum ADP concentrations were significantly lower in acute myocardial infarction (AMI) and unstable angina pectoris (UAP) groups compared to stable angina pectoris (SAP) and control groups.
  • hsCRP concentrations were significantly higher in AMI and UAP groups than in SAP and control groups.
  • A negative correlation was observed between ADP and hsCRP in the acute coronary syndrome group (r = -0.33, p < 0.05).
  • Increased cardiovascular risk factors were associated with lower serum ADP levels in CAD patients.

Conclusions:

  • Serum adiponectin (ADP) is linked to coronary artery disease (CAD) and cardiovascular risk factors.
  • ADP exhibits anti-inflammatory and anti-atherogenic properties.
  • ADP may hold predictive value for the development and progression of acute coronary syndromes (ACS).
Abstract

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