Related Experiment Video
Updated: May 13, 2026
Drug Screening of Primary Patient Derived Tumor Xenografts in Zebrafish
Published on: April 10, 2020
Potential of zebrafish for anticancer drug screening
1Stem Cell Program and Hematology/Oncology, Children's Hospital Howard Hughes Medical Institute Harvard Medical School, Boston, MA 02115, USA +1 617 919 2069 ; +1 617 730 0222 ; zon@enders.tch.harvard.edu.
Background:
The zebrafish is a powerful vertebrate model organism for large scale genetic and chemical screens.
Objective:
With the rapid development of cancer modeling in zebrafish, great opportunities exist for chemical screens to find anticancer agents.
Methods:
Using embryos, pathway screens can be designed based on our knowledge of cancer biology. Anticancer chemical screens using tumor bearing adult zebrafish facilitate preclinical testing.
Conclusion:
Current developments in improving cancer models and automated imaging technology have the potential of finding novel compounds that disrupt tumor biology.
