Oligonucleotidic therapeutics
Yoshitaka Isaka1, Enyu Imai, Shiro Takahara
1Osaka University Graduate School of Medicine, Departments of Advanced Technology for Transplantation, Suite 565-0871, Japan +81 6 6879 3746; +81 6 6879 3749 ; isaka@att.med.osaka-u.ac.jp.
Abstract:
Numerous oligonucleotide-based biopharmaceuticals have been tested to suppress disease progression. These potent therapeutics include plasmids containing transgenes, antisense oligonucleotides, ribozymes, DNAzymes, decoys, aptamers and small interfering RNAs. This perspective discusses the mechanisms and clinical applications of such oligonucleotidic therapeutics. In addition, the most promising oligonucleotides, antisense oligonucleotides and small interfering RNAs, are discussed with regard to future applications.
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