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Updated: May 13, 2026

Surgical Swine Model of Chronic Cardiac Ischemia Treated by Off-Pump Coronary Artery Bypass Graft Surgery
Published on: March 27, 2018
Cognitive outcome after on- and off-pump coronary artery bypass grafting surgery: a systematic review and
Ewan D Kennedy1, Kevin C C Choy, R Peter Alston
1The University of Edinburgh, College of Medicine and Veterinary Medicine, Edinburgh, UK. E.D.Kennedy@sms.ed.ac.uk
Objective:
The aim of this study was to compare cognition following coronary artery bypass grafting (CABG) surgery with or without cardiopulmonary bypass (CPB) (on- or off-pump).
Design:
Systematic review and meta-analysis of randomized control trials comparing cognitive outcome in patients undergoing CABG surgery on- or off-pump as assessed by continuous measures from a battery of 7 psychometric tests.
Setting:
Multi-institutional centers performing CABG surgery.
Participants:
Patients with coronary artery disease requiring CABG surgery.
Interventions:
CABG surgery with or without CPB.
Measurements And Main Results:
A structured literature search identified 13 randomized control trials that included a total of 2,405 patients. Results from 7 psychometric tests were grouped into early (≤3 months) and late (6-12 months) postoperative periods. No significant differences were found between on- and off-pump groups in any of the 7 psychometric tests in either the early (p range 0.21-0.78) or late (p range 0.09-0.93) postoperative period.
Conclusion:
The results suggested that CPB may not be associated with cognitive decline that is associated with CABG surgery.
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