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Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

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Skin Diseases and Disorders

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Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

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Related Experiment Video

Updated: May 13, 2026

Humanized Mouse Model to Study Bacterial Infections Targeting the Microvasculature
11:40

Humanized Mouse Model to Study Bacterial Infections Targeting the Microvasculature

Published on: April 1, 2014

Infections in vasculitis.

Loïc Guillevin1

  • 1Department of Internal Medicine, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Université Paris Descartes, 27, rue du faubourg Saint-Jacques, 75679 Paris Cedex, France. loic.guillevin@cch.aphp.fr

Best Practice & Research. Clinical Rheumatology
|March 20, 2013
PubMed
Summary

Infections can cause vasculitis and frequently occur in patients undergoing treatment. Close monitoring of immune status and prophylactic measures are crucial for high-risk patients to prevent infections.

Area of Science:

  • Infectious disease
  • Rheumatology
  • Immunology

Background:

  • Infections are implicated in various vasculitides, including those caused by hepatitis B and C viruses.
  • Other infectious agents like HIV, EBV, and parvovirus are also hypothesized to contribute to vasculitis.
  • A Burkholderia-like strain has been identified as a cause of giant-cell arteritis.

Purpose of the Study:

  • To explore the relationship between infections and vasculitis.
  • To discuss the increased risk of infections in patients treated for vasculitis.
  • To recommend monitoring and prophylactic strategies for infection prevention.

Main Methods:

  • Literature review of infectious causes of vasculitis.
  • Analysis of infection risks associated with immunosuppressive therapies.

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In Vitro and In Vivo Model to Study Bacterial Adhesion to the Vessel Wall Under Flow Conditions
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In Vitro and In Vivo Model to Study Bacterial Adhesion to the Vessel Wall Under Flow Conditions

Published on: June 11, 2015

Related Experiment Videos

Last Updated: May 13, 2026

Humanized Mouse Model to Study Bacterial Infections Targeting the Microvasculature
11:40

Humanized Mouse Model to Study Bacterial Infections Targeting the Microvasculature

Published on: April 1, 2014

In Vitro and In Vivo Model to Study Bacterial Adhesion to the Vessel Wall Under Flow Conditions
10:24

In Vitro and In Vivo Model to Study Bacterial Adhesion to the Vessel Wall Under Flow Conditions

Published on: June 11, 2015

  • Review of immunological monitoring parameters and prophylaxis.

    • Main Results:

    • Viral infections are common causes of vasculitis (e.g., hepatitis B in polyarteritis nodosa, hepatitis C in mixed cryoglobulinemia).
    • Patients on immunosuppressants (steroids, cytotoxic agents, biologics) for vasculitis have a high risk of infections, especially long-term.
    • Elderly patients and those in poor general condition are more susceptible to infections.

    Conclusions:

    • Close monitoring of immunological status (neutrophils, lymphocytes, CD cell counts, gammaglobulins) is essential for patients at risk.
    • Prophylaxis is recommended for patients at high risk of developing infections during vasculitis treatment.
    • Understanding the infectious etiology and treatment-related risks is key to managing vasculitis patients.