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Updated: May 13, 2026

Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
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Thyroid function and cognition in the euthyroid elderly: a case-control study embedded in Quebec longitudinal study -

Christian-Alexandre Castellano1, Danielle Laurin, Marie-France Langlois

  • 1Research Center on Aging, Sherbrooke, QC, Canada J1H 4C4; Department of Physiology and Biophysics, Université de Sherbrooke, Sherbrooke, QC, Canada J1H 5N4.

Psychoneuroendocrinology
|March 20, 2013
PubMed
Summary
This summary is machine-generated.

Thyroid stimulating hormone (TSH) and thyroid hormones show no significant link to cognitive decline in euthyroid older adults over three years. This study suggests thyroid function is not a key factor in age-related cognitive changes.

Keywords:
AgingCognitionEuthyroidismNuAge cohortTSHThyroid hormones

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A Versatile, Behavioral Method to Investigate Thyroid Hormone Effects on Cerebellar Function
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Area of Science:

  • Gerontology
  • Endocrinology
  • Neuroscience

Background:

  • Cognitive decline is a major concern in aging populations.
  • The role of thyroid function in cognitive health among euthyroid elderly remains unclear.
  • Existing research has not definitively established a link between thyroid hormones and cognitive decline in this demographic.

Purpose of the Study:

  • To investigate the association between thyroid function indices and the risk of cognitive decline over a three-year period.
  • To examine serum levels of thyroid stimulating hormone (TSH), total thyroxine, free thyroxine, total triiodothyronine, and free triiodothyronine.
  • To determine if thyroid function impacts cognitive changes in euthyroid individuals aged 67 and older.

Main Methods:

  • A case-control study design was employed using a subsample from the NuAge study.
  • Participants (62 individuals, 31 matched pairs) were aged 67+ at baseline and matched for age, sex, and global cognition.
  • Thyroid function indices and cognitive decline (measured by Modified Mini-Mental State Examination - 3MS) were assessed over three years using conditional logistic regression models.

Main Results:

  • No significant association was found between any measured thyroid function indices (TSH, T4, T3) and the 3-year risk of cognitive decline.
  • Thyroid stimulating hormone and thyroid hormones did not appear to be predictive of cognitive decline in the studied euthyroid elderly population.
  • The Modified Mini-Mental State Examination (3MS) did not show a correlation with thyroid function markers in this cohort.

Conclusions:

  • Thyroid function, including TSH and thyroid hormones, does not seem to be significantly associated with cognitive decline in euthyroid older individuals.
  • These findings suggest that maintaining normal thyroid function may not be a direct intervention target for preventing cognitive decline in the elderly.
  • Further research with larger sample sizes is recommended to confirm these results due to the study's limited number of participants.