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TNF-α polymorphisms and coronary artery disease: association study in the Korean population

Ho-Chan Cho1, Gyeongim Yu, Mi-Young Lee

  • 1Department of Internal Medicine, Keimyung University, DongSan Medical Center, Daegu, South Korea.

Cytokine
|March 20, 2013
PubMed

Insights

Tumor necrosis factor-alpha (TNF-α) gene promoter polymorphisms, specifically the -238A allele, are linked to an increased risk of coronary artery disease (CAD) in Koreans. This finding may aid in predicting CAD incidence in this population.

Area of Science:

  • Genetics
  • Cardiology
  • Immunology

Background:

  • Coronary artery disease (CAD) stems from atherosclerosis, a chronic inflammatory process.
  • Proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), play a role in mediating atherosclerosis.
  • TNF-α is expressed by atherosclerotic plaques, suggesting a potential link to disease development.

Purpose of the Study:

  • To investigate the association between TNF-α gene promoter polymorphisms and the incidence of CAD in the Korean population.
  • To determine if specific TNF-α gene variants act as predictive markers for CAD risk.

Main Methods:

  • Genotyping of 197 CAD patients and 404 control subjects for TNF-α polymorphisms at positions -238, -857, and -863.
  • Statistical analysis, including dominant inheritance models, allele association, haplotype analysis, and multivariate analysis.
  • Adjustments for factors like body mass index, diabetes, and hypertension.

Main Results:

  • The G/A polymorphism at TNF-α position -238 was significantly associated with CAD (OR = 1.87, P = 0.02).
  • Carriers of the -238A allele showed a higher risk of developing CAD (OR = 1.74, P = 0.03).
  • Haplotype analysis revealed significant differences in ACC haplotype frequencies between CAD patients and controls (OR = 1.77, P = 0.03), confirmed by multivariate analysis (OR = 2.06, P = 0.015).
  • Polymorphisms at -857 and -863 were not associated with CAD.

Conclusions:

  • The -238A allele of the TNF-α gene is associated with an increased risk of CAD in Koreans.
  • This specific TNF-α polymorphism may serve as a potential predictor for CAD in the Korean population.
  • Further research is warranted to fully understand the clinical implications of these genetic associations.

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