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Updated: May 13, 2026

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
Published on: April 5, 2017
Efficacy of nitazoxanide against clinical isolates of Mycobacterium tuberculosis
Kristina Shigyo1, Oksana Ocheretina, Yves Mary Merveille
1Center for Global Health, Department of Medicine, Weill Cornell Medical College, New York, New York, USA.
Abstract:
Nitazoxanide (NTZ) has bactericidal activity against the H37Rv laboratory strain of Mycobacterium tuberculosis with a MIC of 16 μg/ml. However, its efficacy against clinical isolates of M. tuberculosis has not been determined. We found that NTZ's MIC against 50 clinical isolates ranged from 12 to 28 μg/ml with a median of 16 μg/ml and was unaffected by resistance to first- or second-line antituberculosis drugs or a diversity of spoligotypes.
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