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Updated: May 13, 2026

An Air-liquid Interface Bronchial Epithelial Model for Realistic, Repeated Inhalation Exposure to Airborne Particles for Toxicity Testing
Published on: May 13, 2020
Ciprofloxacin is actively transported across bronchial lung epithelial cells using a Calu-3 air interface cell model
Hui Xin Ong1, Daniela Traini, Mary Bebawy
1Respiratory Technology, Woolcock Institute of Medical Research, Sydney, NSW, Australia.
Abstract:
Ciprofloxacin is a well-established broad-spectrum fluoroquinolone antibiotic that penetrates well into the lung tissues; still, the mechanisms of its transepithelial transport are unknown. The contributions of specific transporters, including multidrug efflux transporters, organic cation transporters, and organic anion-transporting polypeptide transporters, to the uptake of ciprofloxacin were investigated in vitro using an air interface bronchial epithelial model. Our results demonstrate that ciprofloxacin is subject to predominantly active influx and a slight efflux component.
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