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Updated: May 13, 2026

Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase

Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase

Published on: October 15, 2018

DNA methyltransferases in hematologic malignancies.

Keqin Kathy Li¹, Liu-Fei Luo, Yang Shen

¹State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital Affiliated to Shanghai JiaoTong University School of Medicine, Shanghai, China.

Seminars in Hematology

|March 20, 2013

Summary

This summary is machine-generated.

DNA methyltransferases (DNMTs) regulate gene expression and are crucial for hematopoietic stem cell function. Aberrant DNMTs are linked to blood cancers, offering potential for new epigenetic drug targets.

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Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells

Identifying DNA Mutations in Purified Hematopoietic Stem/Progenitor Cells

Published on: February 24, 2014

Area of Science:

Epigenetics
Molecular Biology
Hematology

Background:

DNA methyltransferases (DNMTs) are critical enzymes for genome methylation, influencing gene expression.
DNA methylation is vital for hematopoietic stem cell (HSC) self-renewal and differentiation.
Mutations in DNMTs are increasingly identified in hematologic malignancies.

Purpose of the Study:

To review the biology of DNMTs in epigenetic regulation.
To explore the role of DNMTs in HSC and leukemia stem cell (LSC) biology.
To discuss DNMTs in the context of hematologic malignancies and drug discovery.

Main Methods:

Literature review of studies on DNMTs, DNA methylation, and hematologic malignancies.
Analysis of mouse models with conditional knockout of DNMT1 and DNMT3A.
Examination of functional analyses of DNMT mutations in cancer.

Main Results:

DNMTs play key roles in HSC and LSC regulation.
DNMT3A mutations are prevalent in hematologic malignancies.
DNMT inhibitors are emerging as therapeutic agents for blood cancers.

Conclusions:

Understanding DNMT biology is crucial for deciphering hematologic malignancy mechanisms.
DNMT mutations may serve as biomarkers and drug targets.
Epigenetic therapies targeting DNMTs show promise for treating MDS and AML.