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Related Concept Videos

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices01:28

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...
Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...

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Related Experiment Video

Updated: May 13, 2026

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices
10:22

High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices

Published on: September 2, 2009

Recent technologies in pulsatile drug delivery systems.

Deepika Jain1, Richa Raturi, Vikas Jain

  • 1Bhagyoday Tirth Pharmacy College, Sagar, Madhya Pradesh, India.

Biomatter
|March 20, 2013
PubMed
Summary
This summary is machine-generated.

Pulsatile drug delivery systems (PDDS) offer superior benefits over conventional methods by releasing medication in pulses, improving therapeutic outcomes and patient compliance. These advanced systems are ideal for drugs requiring precise timing or facing the first-pass effect.

Keywords:
capsular systempulsatile drug delivery systempulserupturable coating

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High Speed Droplet-based Delivery System for Passive Pumping in Microfluidic Devices
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Published on: September 27, 2021

Area of Science:

  • Pharmaceutical Sciences
  • Drug Delivery Systems
  • Chronopharmacology

Background:

  • Conventional drug delivery systems often lack the precision for drugs with circadian-dependent efficacy or those affected by first-pass metabolism.
  • Pulsatile drug delivery systems (PDDS) offer a targeted approach, releasing medication in specific amounts at desired times and locations.
  • These systems align with the body's natural rhythms, enhancing therapeutic benefits and patient adherence.

Purpose of the Study:

  • To review the methods and marketed technologies for achieving pulsatile drug release.
  • To highlight the advantages of PDDS over traditional dosage forms.
  • To explore the potential applications of PDDS in treating various diseases.

Main Methods:

  • Review of scientific literature and marketed pulsatile drug delivery technologies.
  • Analysis of drug release profiles, focusing on sigmoidal patterns and lag times.
  • Identification of diseases and drug types suitable for pulsatile delivery.

Main Results:

  • PDDS provide precise drug release, mimicking the body's circadian rhythm with a lag time followed by rapid, complete drug release.
  • Marketed technologies like Pulsincap™, Diffucaps®, CODAS®, OROS®, and PULSYS™ utilize mechanisms to achieve sigmoidal release profiles.
  • PDDS demonstrate significant promise for treating conditions such as asthma, peptic ulcers, cardiovascular diseases, arthritis, and hypercholesterolemia.

Conclusions:

  • Pulsatile drug delivery systems represent a significant advancement over conventional dosage forms, offering enhanced efficacy and patient compliance.
  • The precise, time-controlled release of PDDS is particularly beneficial for drugs with chronopharmacological properties or those subject to first-pass metabolism.
  • PDDS hold substantial potential for revolutionizing the treatment of numerous diseases, paving the way for innovative therapeutic strategies.