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Published on: July 19, 2018
The peritoneal-renal syndrome
Sharon J Nessim1, Joanne M Bargman
1Division of Nephrology, Jewish General Hospital, McGill University, Montreal, QC, Canada.
Nature Reviews. Nephrology
|March 20, 2013
Summary
Peritoneal dialysis (PD) patients experience a strong connection between their peritoneal membrane and kidneys. This article introduces the
Area of Science:
- Nephrology
- Peritoneal Dialysis
- Renal Physiology
Background:
- Patients on peritoneal dialysis (PD) exhibit a significant interplay between the peritoneal membrane and kidney function.
- Understanding this relationship is crucial for managing PD patients' overall health.
Purpose of the Study:
- To explore the mechanisms linking peritoneal membrane function and residual renal function in PD patients.
- To discuss the concurrent effects of PD solutions and renin-angiotensin-aldosterone system inhibitors on both organs.
- To propose a novel concept of 'peritoneal-renal syndrome'.
Main Methods:
- Review of existing literature on peritoneal membrane function and renal function in PD.
- Analysis of the impact of PD solutions and pharmacological agents.
- Conceptual framework development for 'peritoneal-renal syndrome'.
Main Results:
- Alterations in peritoneal membrane function can impact residual renal function, and vice versa.
- PD solutions and renin-angiotensin-aldosterone system inhibitors can affect both the peritoneal membrane and kidneys simultaneously.
- Evidence supports a complex, bidirectional interaction between the peritoneal membrane and kidneys.
Conclusions:
- The concept of 'peritoneal-renal syndrome' is proposed to describe the intricate relationship between the peritoneal membrane and kidneys in PD patients.
- This syndrome highlights the need for a holistic approach to managing PD patients, considering the interconnectedness of these organs.
- Further research is warranted to elucidate the specific mechanisms and clinical implications of the peritoneal-renal syndrome.
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