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Updated: May 13, 2026

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Published on: July 17, 2012

X-ray fluorescence tomographic system design and image reconstruction.

Wenxiang Cong¹, Haiou Shen, Guohua Cao

¹School of Biomedical Engineering and Sciences, Virginia Tech, Blacksburg, VA, USA.

Journal of X-Ray Science and Technology

|March 20, 2013

Summary

This study introduces a novel X-ray fluorescence computed tomography (XFCT) system for in-vivo imaging. The new XFCT design enhances detection efficiency and reduces radiation dose, showing promise for molecular imaging in research and clinical settings.

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Last Updated: May 13, 2026

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Published on: July 17, 2012

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X-ray Dose Reduction through Adaptive Exposure in Fluoroscopic Imaging

X-ray Dose Reduction through Adaptive Exposure in Fluoroscopic Imaging

Published on: September 11, 2011

Area of Science:

Medical Imaging
Biomedical Engineering
Nanotechnology

Background:

X-ray fluorescence computed tomography (XFCT) is a valuable molecular imaging technique.
In-vivo detection of gold nanoparticles (GNPs) requires efficient signal acquisition and minimal radiation exposure.
Existing XFCT systems face challenges in sensitivity and dose reduction.

Purpose of the Study:

To present a new XFCT system design for enhanced in-vivo fluorescence imaging of gold nanoparticles.
To improve detection efficiency and reduce radiation dose during tomographic scans.
To evaluate the system's sensitivity and potential for small animal research and clinical translation.

Main Methods:

A novel XFCT system design featuring multiple spectroscopic detectors arranged orthogonally to the region of interest.
Implementation of excitation filtration to minimize low-energy X-rays and background scattering.
Numerical simulations to assess radiation dose and detection sensitivity.

Main Results:

The system achieves localized scans with maximized efficiency for in-vivo GNP detection.
Radiation dose is simulated to be below 300 mGy/second for a 30-view tomographic scan.
Sensitivity for 3D fluorescence signal detection reaches up to 0.2% contrast concentrations of nanoparticles.

Conclusions:

The developed XFCT system is an effective molecular imaging tool for small animal research.
The system demonstrates significant potential for future clinical applications in molecular imaging.
The design improvements offer enhanced sensitivity and reduced radiation dose compared to conventional methods.