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Related Experiment Video

Updated: May 13, 2026

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
09:22

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications

Published on: August 28, 2015

Multifunctional aliphatic polyester nanofibers for tissue engineering.

Jianan Zhan1, Anirudha Singh, Zhe Zhang

  • 1Wilmer Eye Institute and Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, USA.

Biomatter
|March 20, 2013
PubMed
Summary
This summary is machine-generated.

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Researchers developed novel poly(ε-caprolactone)-α-cyclodextrin (PCL-α-CD) nanofibers for regenerative medicine. These PCL-α-CD scaffolds enhance cell differentiation and tissue regeneration without altering the PCL backbone.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Polymer Chemistry

Background:

  • Aliphatic polyesters like poly(ε-caprolactone) (PCL) are widely used in regenerative medicine and drug delivery.
  • However, PCL fibers are hydrophobic, limiting their wettability and functionalization for bioactive cues.
  • Existing methods to improve PCL properties involve chemical modifications or blending, which can be complex.

Purpose of the Study:

  • To design multifunctional electrospun nanofibers using a PCL-α-cyclodextrin (PCL-α-CD) inclusion complex.
  • To provide a PCL-based scaffold with inherent functionality for bioactive component conjugation without altering the PCL main chain.
  • To evaluate the potential of these PCL-α-CD nanofibers in promoting osteogenic differentiation of human adipose-derived stem cells (hADSCs).

Main Methods:

Keywords:
Poly(ε-caprolactone)electrospinningnanofiberstissue engineeringα-cyclodextrin

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Published on: June 18, 2014

Synthesis of Keratin-based Nanofiber for Biomedical Engineering
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Synthesis of Keratin-based Nanofiber for Biomedical Engineering

Published on: February 7, 2016

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Last Updated: May 13, 2026

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
09:22

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications

Published on: August 28, 2015

Electrospun Fibrous Scaffolds of Poly(glycerol-dodecanedioate) for Engineering Neural Tissues From Mouse Embryonic Stem Cells
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Electrospun Fibrous Scaffolds of Poly(glycerol-dodecanedioate) for Engineering Neural Tissues From Mouse Embryonic Stem Cells

Published on: June 18, 2014

Synthesis of Keratin-based Nanofiber for Biomedical Engineering
14:43

Synthesis of Keratin-based Nanofiber for Biomedical Engineering

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  • Synthesis of PCL-α-CD inclusion complex electrospun nanofibers.
  • Characterization of the composition and structure of the PCL-α-CD nanofibers.
  • Conjugation of a fluorescent small molecule and polymeric nanobeads to demonstrate functionalization.
  • In vitro evaluation of PCL-α-CD nanofibers for promoting osteogenic differentiation of hADSCs.

Main Results:

  • Successful synthesis and characterization of PCL-α-CD electrospun nanofibers.
  • Demonstrated facile conjugation of small molecules and nanobeads to the functionalized nanofibers.
  • PCL-α-CD nanofibers significantly promoted osteogenic differentiation of hADSCs compared to control PCL fibers.
  • Enhanced expression of osteogenic markers and increased extracellular matrix (ECM) production were observed in cells cultured on PCL-α-CD scaffolds.

Conclusions:

  • PCL-α-CD inclusion complex nanofibers offer a versatile and easily fabricated platform for regenerative medicine applications.
  • The strategy provides inherent functionality without chemical modification of the PCL backbone.
  • These nanofibers show promise for enhancing bone tissue regeneration by promoting osteogenic differentiation of stem cells.