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Labeling DNA Probes

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...

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Related Experiment Video

Updated: May 13, 2026

Identification of Small Molecule-binding Proteins in a Native Cellular Environment by Live-cell Photoaffinity Labeling

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Target validation using chemical probes

Mark E Bunnage¹, Eugene L Piatnitski Chekler, Lyn H Jones

¹Worldwide Medicinal Chemistry at Pfizer, Cambridge, Massachusetts, USA. mark.bunnage@pfizer.com

Nature Chemical Biology

|March 20, 2013

Summary

No abstract available in PubMed .

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