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Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Peripheral Artery Disease I: Introduction01:30

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Atherosclerosis I: Introduction01:30

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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...

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Related Experiment Video

Updated: May 13, 2026

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy
10:35

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

Published on: October 19, 2016

Arterial ageing.

Seung-Jun Lee1, Sung-Ha Park

  • 1Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea.

Korean Circulation Journal
|March 20, 2013
PubMed
Summary
This summary is machine-generated.

Arterial aging accelerates due to oxidative stress and inflammation, particularly from hypertension. This review explores modifiable factors and novel therapeutic targets for arterial aging.

Keywords:
AgingArterial stiffnessAtherosclerosisPulse wave analysis

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Isolation and Functional Analysis of Arteriolar Endothelium of Mouse Brain Parenchyma
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Related Experiment Videos

Last Updated: May 13, 2026

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy
10:35

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

Published on: October 19, 2016

Isolation and Functional Analysis of Arteriolar Endothelium of Mouse Brain Parenchyma
06:40

Isolation and Functional Analysis of Arteriolar Endothelium of Mouse Brain Parenchyma

Published on: March 11, 2022

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues
08:41

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

Area of Science:

  • Cardiovascular Science
  • Aging Research
  • Pathophysiology

Background:

  • Arterial aging involves media layer degeneration and sclerosis.
  • Oxidative stress and inflammation accelerate arterial aging beyond natural processes.
  • Clinical conditions significantly impact the rate of arterial aging.

Purpose of the Study:

  • To review the pathophysiology of arterial aging.
  • To identify and summarize factors accelerating arterial aging.
  • To explore novel treatment targets for accelerated arterial aging.

Main Methods:

  • Literature review summarizing existing research.
  • Focus on modifiable factors like hypertension and inflammation.
  • Analysis of disease models, including Hutchinson Gilford Progeria Syndrome.

Main Results:

  • Hypertension, renin-angiotensin-aldosterone system activation, and vascular inflammation are key accelerators.
  • These factors contribute to media degeneration and arterial sclerosis.
  • Hutchinson Gilford Progeria Syndrome offers insights into novel therapeutic targets.

Conclusions:

  • Arterial aging is influenced by both natural processes and accelerated factors.
  • Modifiable factors present opportunities for therapeutic intervention.
  • Further research into novel targets may mitigate accelerated arterial aging.