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Extracapsular spread in hypopharyngeal squamous cell carcinoma: diagnostic value of FDG PET/CT
Young-Hoon Joo1, Ie-Ryung Yoo, Kwang-Jae Cho
1Department of Otolaryngology - Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Background:
The purpose of this study was to evaluate the use of fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT for the identification of extracapsular spread (ECS) with supporting histologic correlation in hypopharyngeal cancer.
Method:
We retrospectively reviewed the medical records of 57 patients who underwent FDG PET/CT for hypopharyngeal cancer.
Results:
ECS was present in 79% dissected necks (45 of 57 patients) and in 64% dissected cervical levels (55 of 86). A significant difference in standardized uptake value maximum (SUVmax ) values was found between cervical lymph nodes with and without ECS (6.10 ± 3.51 vs 1.75 ± 1.46, respectively; p < .001). The cutoff value of SUVmax for differentiating with and without ECS was 2.65 with a sensitivity of 80% and a specificity of 74%. The presence of ECS and median SUVmax were found to have a significant adverse effect on 5-year disease-specific survival.
Conclusion:
Median FDG PET/CT SUVmax cutoff values of 2.65 or greater are associated with a greater risk of ECS in cervical lymph node metastasis from hypopharyngeal squamous cell carcinoma (SCC).
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