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Increased pulse wave velocity and carotid intima-media thickness in patients with ulcerative colitis

Remzi Adnan Akdoğan1, Murtaza Emre Durakoğlugil, Sinan Altan Kocaman

  • 1Department of Gastroenterology, Faculty of Medicine, Recep Tayyip Erdoğan University, Rize, Turkey.

Digestive Diseases and Sciences
|March 20, 2013
PubMed

Insights

This study found that ulcerative colitis (UC) patients have increased arterial stiffness and atherosclerosis. These findings suggest a link between UC and cardiovascular risk factors.

Area of Science:

  • Cardiovascular Medicine
  • Gastroenterology
  • Vascular Biology

Background:

  • Ulcerative colitis (UC) is a chronic inflammatory bowel disease.
  • The relationship between UC and cardiovascular disease (CVD) remains unclear.

Purpose of the Study:

  • To assess atherosclerosis and arterial stiffness in UC patients.
  • Investigate carotid intima-media thickness (CIMT) and carotid-femoral pulse wave velocity (cf-PWV) in UC.

Main Methods:

  • Cross-sectional, observational study design.
  • 37 UC patients and 30 controls underwent CIMT and cf-PWV measurements.
  • Exclusion of patients with prior CVD or other inflammatory conditions.

Main Results:

  • UC patients exhibited significantly higher CIMT and cf-PWV.
  • UC was an independent predictor of CIMT.
  • Higher disease activity correlated with increased CIMT and cf-PWV.

Conclusions:

  • UC is associated with increased arterial stiffness and atherosclerotic burden.
  • Underlying mechanisms require further investigation.
Abstract

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