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Related Experiment Video

Updated: May 13, 2026

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging

Published on: September 12, 2011

White matter and visuospatial processing in autism: a constrained spherical deconvolution tractography study.

Jane McGrath1, Katherine Johnson, Erik O'Hanlon

  • 1Department of Psychiatry, Trinity Centre for Health Sciences, St James's Hospital, Dublin, Ireland.

Autism Research : Official Journal of the International Society for Autism Research
|March 20, 2013
PubMed
Summary
This summary is machine-generated.

Individuals with autism spectrum disorder (ASD) show altered white matter organization in the right inferior fronto-occipital fasciculus (IFOF). This disruption is linked to poorer visuospatial processing abilities in ASD.

Keywords:
autismconstrained spherical deconvolutiondiffusion MRIinferior fronto-occipital fasciculustractographyvisuospatial processing

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Related Experiment Videos

Last Updated: May 13, 2026

Probing the Brain in Autism Using fMRI and Diffusion Tensor Imaging
12:21

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Published on: September 12, 2011

Measuring Connectivity in the Primary Visual Pathway in Human Albinism Using Diffusion Tensor Imaging and Tractography
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Published on: August 11, 2016

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging

Published on: November 8, 2012

Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Neuroimaging

Background:

  • Autism spectrum disorders (ASDs) are linked to disrupted neural connectivity and white matter organization.
  • Understanding white matter alterations is crucial for explaining cognitive differences in ASD.

Purpose of the Study:

  • To investigate major intrahemispheric white matter tracts in autism using advanced tractography.
  • To characterize the microstructural organization of the inferior fronto-occipital fasciculus (IFOF) and arcuate fasciculus in individuals with ASD.
  • To associate white matter organization with visuospatial processing performance.

Main Methods:

  • Employed constrained spherical deconvolution (CSD)-based tractography, an advanced diffusion imaging technique.
  • Isolated the inferior fronto-occipital fasciculus (IFOF) and arcuate fasciculus in 25 participants with ASD and 25 age- and IQ-matched controls.
  • Acquired high angular resolution diffusion imaging (HARDI) data.

Main Results:

  • Significant alterations in white matter microstructural organization were found in the right IFOF of individuals with ASD.
  • Poorer visuospatial processing performance in the ASD group was associated with disrupted white matter in the right IFOF.
  • CSD-based tractography revealed novel insights into white matter abnormalities in ASD.

Conclusions:

  • This study demonstrates significant alterations in the right IFOF's white matter microstructural organization in ASD.
  • These structural brain abnormalities may underlie atypical visuospatial processing in individuals with autism.
  • Highlights the utility of advanced CSD-based tractography in autism research.