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Updated: May 13, 2026

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
Published on: April 9, 2014
Enhanced replication of R5 HIV-1 isolates in vitro by a small-molecule reagent targeting HIV-1 protease
Nick J Wardle1, Harry R Hudson, Ray W Matthews
1Institute for Health Research and Policy, London Metropolitan University, 166-220 Holloway Rd, London N7 8DB, UK. n.wardle@londonmet.ac.uk
Abstract:
CHEMICAL ENHANCEMENT: Designed to target HIV-1 protease, a novel γ-hydroxyphosphonate has been found to significantly enhance viral replication in a panel of clinically relevant R5 HIV-1 isolates. This unexpected result constitutes the first instance of a small molecule capable of doing this, and it has implications for the preparation and use of R5 isolates in vaccine and drug development.
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