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Related Concept Videos

COPD: Management Using Bronchodilators and Corticosteroids01:26

COPD: Management Using Bronchodilators and Corticosteroids

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Related Experiment Video

Updated: May 13, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Heliox therapy in bronchiolitis: phase III multicenter double-blind randomized controlled trial.

Mina M Chowdhury1, Sheila A McKenzie, Christopher C Pearson

  • 1Department of Pediatrics, Wright Fleming Institute, Imperial College, London, United Kingdom.

Pediatrics
|March 20, 2013
PubMed
Summary
This summary is machine-generated.

Helium-oxygen (Heliox) therapy for infant bronchiolitis did not reduce hospital length of treatment overall. However, Heliox significantly shortened treatment for infants receiving it via facemask or continuous positive airway pressure (CPAP).

Related Experiment Videos

Last Updated: May 13, 2026

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
14:39

Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

Published on: November 4, 2010

Area of Science:

  • Pediatric Respiratory Medicine
  • Critical Care
  • Neonatology

Background:

  • Supportive care is the primary treatment for infant bronchiolitis.
  • Limited evidence exists on the efficacy of helium-oxygen (Heliox) therapy for bronchiolitis.
  • This study compares Heliox with standard air-oxygen (Airox) therapy.

Purpose of the Study:

  • To compare the efficacy of Heliox and Airox in reducing the length of hospital treatment for infant bronchiolitis.
  • To evaluate the impact of delivery method (facemask vs. nasal cannula) and continuous positive airway pressure (CPAP) on treatment outcomes.

Main Methods:

  • A multicenter randomized blinded controlled trial involving 319 infants with bronchiolitis.
  • Infants were randomly assigned to receive either Heliox or Airox.
  • Treatment was administered via facemask or nasal cannula, with or without CPAP.

Main Results:

  • Overall, Heliox did not significantly reduce the length of hospital treatment (LoT) compared to Airox (P = .41).
  • In the facemask-tolerant subgroup, Heliox significantly reduced LoT (P = .03).
  • Heliox significantly reduced LoT when initiated with CPAP (P = .02) and improved respiratory distress scores within 8 hours (P < .001).

Conclusions:

  • Heliox therapy is ineffective for reducing hospital LoT in infant bronchiolitis when delivered via nasal cannula.
  • Heliox therapy can reduce LoT and respiratory distress when administered via a tight-fitting facemask or with CPAP.
  • The delivery method is critical for the efficacy of Heliox in treating infant bronchiolitis.