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Analyzing Platelet Subpopulations by Multi-color Flow Cytometry
Published on: June 10, 2025
Galectins: new agonists of platelet activation
Mirta Schattner1, Gabriel A Rabinovich
1Laboratory of Experimental Thrombosis, Institute of Experimental Medicine IMEX/CONICET, National Academy of Medicine, C1425, Buenos Aires, Argentina. mschattner@hotmail.com
Abstract:
Platelet activation at sites of vascular injury leads to the formation of a hemostatic plug and is crucial for hemostasis. However, uncontrolled platelet activation may lead to the formation of occlusive thrombi. Several soluble or matricellular proteins can activate platelets. In this article, we review recent advances in knowledge of the role of galectins in platelet physiology. In soluble or immobilized form, these endogenous glycan-binding proteins trigger platelet activation through the modulation of discrete signaling pathways. We discuss the role of platelet-galectin interactions not only in hemostasis, but also in chronic inflammation, atherosclerosis and cancer.
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