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Related Experiment Videos

[Pituitary apoplexy with hypercreatinekinasemia].

Y Mitsuhata1, Y Yano, T Muro

  • 1Department of Neurology, Tokyo Metropolitan Komagome Hospital.

Rinsho Shinkeigaku = Clinical Neurology
|February 1, 1990
PubMed
Summary
This summary is machine-generated.

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This study presents a case of pituitary apoplexy with hypercreatinekinasemia. The patient

Area of Science:

  • Neurology
  • Endocrinology

Background:

  • Pituitary apoplexy is a rare endocrine emergency.
  • Hypercreatinekinasemia is typically associated with muscle injury or cerebrovascular accidents.

Observation:

  • A 59-year-old female presented with symptoms of pituitary apoplexy including headache, nausea, vomiting, and pyrexia.
  • Cranial nerve examination was normal, but cerebrospinal fluid analysis showed elevated protein and cell counts.
  • Imaging revealed a ballooning sella turcica, leading to a diagnosis of pituitary apoplexy.

Findings:

  • Surgical removal of necrotic tissue and a chromophobe adenoma was performed via a sphenoidal approach.
  • Serum creatine kinase (CK) levels were significantly elevated (2502 IU/l), with 100% MM isozyme type.
  • CK levels normalized within 12 days post-symptom onset.

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Implications:

  • The elevated CK levels in this case of pituitary apoplexy are unusual.
  • Hypothalamic irritation secondary to pituitary apoplexy may cause muscle enzyme leakage, leading to hypercreatinekinasemia.
  • This case highlights a potential, albeit rare, association between pituitary apoplexy and elevated serum CK.