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Synthesis and evaluation of stable substrate analogs as potential modulators of cyclodiphosphate synthase IspF
J Kipchirchir Bitok1, Caren Freel Meyers
1Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Medchemcomm
|March 20, 2013
Abstract:
Stable IspF substrate analogs were synthesized. In the presence of substrate analogs, the E. coli IspF-MEP complex shows activities distinct from IspF, and bisphosphonates (BP) behave differently than their diphosphate (DP) counterparts. Bisphosphonate analogs activate and/or stabilize IspF, and only the closest structural substrate analog weakly inhibits the IspF-MEP complex.

