Related Experiment Video
Updated: May 13, 2026
Isometric and Eccentric Force Generation Assessment of Skeletal Muscles Isolated from Murine Models of Muscular Dystrophies
Published on: January 31, 2013
Hormonal receptors in skeletal muscles of dystrophic mdx mice
David Feder1, Ivan Rodrigues Barros Godoy, Maira Lazzarini Guimarães Pereira
1Department of Pharmacology, ABC Medical School, FMABC, Avenue Príncipe de Gales 821, 09060-650 Santo Andre, SP, Brazil.
Introduction:
Several evidences show that muscles have an endocrine function. Glucocorticoid, estrogen, progesterone, and testosterone receptors have already been found in normal skeletal muscles, but not in dystrophic muscles.
Methods:
The gene expression of hormone receptors was compared between dystrophic and healthy muscles in mdx and C57BL6 mice strains.
Results:
The mdx mice showed a significant increase in the steroid receptors mRNA when compared to the C57BL6 mice: levels of androgen(s) receptors in the heart, estrogen receptors alpha in the EDL, and estrogen receptors beta in the quadriceps were increased. In addition, significant lowered levels of some other hormone receptors were found: corticosteroid receptors in the EDL and estrogen receptors alpha in the quadriceps.
Conclusion:
Dystrophic muscles bear significant differences in the expression of hormone receptors when compared to the C57BL6 mice strain. The importance of such differences is yet to be better understood.
Related Concept Videos
01:21Satellite Stem Cells and Muscular Dystrophy
01:28Disorders of the Skeletal Muscle
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...