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Coma blisters: report and review.

C Dunn1, J L Held, J Spitz

  • 1Department of Dermatology, Columbia University, College of Physicians and Surgeons, New York, New York.

Cutis
|June 1, 1990
PubMed
Summary
This summary is machine-generated.

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Coma blisters are skin lesions linked to barbiturate overdose and other causes of coma. Biopsies reveal sweat duct necrosis, but these blisters do not indicate infection or rheumatologic issues.

Area of Science:

  • Dermatology
  • Toxicology

Background:

  • Coma blisters are rare skin manifestations observed in patients experiencing coma.
  • These lesions are frequently associated with barbiturate overdose but can occur with other causes of coma.

Observation:

  • Coma blisters present as self-limited cutaneous lesions.
  • Skin biopsy findings are characterized by necrosis of eccrine sweat ducts.

Findings:

  • The etiology of coma blisters is not fully understood.
  • Histopathological examination reveals eccrine sweat duct necrosis as a key feature.
  • Coma blisters are not associated with underlying infections or rheumatologic conditions.

Implications:

  • The presence of coma blisters does not necessitate the discontinuation of barbiturate therapy.

Related Experiment Videos

  • Understanding the pathophysiology of coma blisters can aid in differential diagnosis and patient management.