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A versatile star PEG grafting method for the generation of nonfouling and nonthrombogenic surfaces
Pradeep Kumar Thalla1, Angel Contreras-García, Hicham Fadlallah
1Laboratory of Endovascular Biomaterials (LBeV), Research Centre, Centre Hospitalier de l'Université de Montreal (CRCHUM), 2099 Alexandre de Sève, Montreal, QC, Canada H2L 2W5.
Abstract:
Polyethylene glycol (PEG) grafting has a great potential to create nonfouling and nonthrombogenic surfaces, but present techniques lack versatility and stability. The present work aimed to develop a versatile PEG grafting method applicable to most biomaterial surfaces, by taking advantage of novel primary amine-rich plasma-polymerized coatings. Star-shaped PEG covalent binding was studied using static contact angle, X-ray photoelectron spectroscopy (XPS), and quartz crystal microbalance with dissipation monitoring (QCM-D). Fluorescence and QCM-D both confirmed strong reduction of protein adsorption when compared to plasma-polymerized coatings and pristine poly(ethyleneterephthalate) (PET). Moreover, almost no platelet adhesion was observed after 15 min perfusion in whole blood. Altogether, our results suggest that primary amine-rich plasma-polymerized coatings offer a promising stable and versatile method for PEG grafting in order to create nonfouling and nonthrombogenic surfaces and micropatterns.
