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Central neuropeptide W has anorexigenic effect in rats
T Naso1, S Shousha, A El-Kirdasy
1Department of Veterinary Anatomy and Histology, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan.
Journal of Animal Physiology and Animal Nutrition
|March 21, 2013
Summary
Neuropeptide W (NPW) influences feeding and energy balance. Studies show NPW reduces food intake and increases body temperature, suggesting a key role in regulating energy homeostasis.
Area of Science:
- Neuroendocrinology
- Metabolism
Background:
- Neuropeptide W (NPW) is an endogenous peptide found in the hypothalamus and brain stem.
- NPW acts as a ligand for GPR7 and GPR8 receptors, implicated in energy homeostasis and neuroendocrine functions.
Purpose of the Study:
- To investigate the effects of NPW on feeding intake and energy expenditure in Wistar rats.
Main Methods:
- Systemic administration of NPW (NPW23 and NPW30) and anti-NPW antibodies in Wistar rats.
- Monitoring of feeding intake, body weight, and body temperature.
Main Results:
- Both NPW23 and NPW30 reduced feeding intake, including fasting-induced feeding.
- Chronic NPW23 treatment decreased food consumption and weight gain.
- Anti-NPW antibodies increased feeding intake.
- NPW23 administration elevated body temperature and thermogenesis.
Conclusions:
- Neuropeptide W plays a significant central role in controlling feeding intake and energy balance in mammals.
- NPW may be a therapeutic target for metabolic disorders.
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