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Related Experiment Videos

Transitional mucosa in human colorectal lesions.

M Mori1, R Shimono, Y Adachi

  • 1Division of Clinical Pathology, Kyushu University, Fukuoka, Japan.

Diseases of the Colon and Rectum
|June 1, 1990
PubMed
Summary

Changes in colorectal mucosa, characterized by altered mucin secretion, occur alongside cancerous and precancerous lesions. These mucosal changes appear secondary to the disease, with altered mucus preceding carcinoembryonic antigen expression.

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Area of Science:

  • Gastroenterology
  • Oncology
  • Histopathology

Background:

  • Colorectal disease involves changes in the colonic mucosa.
  • Mucin secretion patterns can be altered in neoplastic conditions.

Purpose of the Study:

  • To investigate mucin-histochemical and immunohistochemical changes in colorectal mucosa adjacent to various lesions.
  • To determine if these mucosal changes are precancerous or secondary phenomena.

Main Methods:

  • Mucin-histochemical analysis of colorectal mucosa.
  • Immunohistochemical staining for carcinoembryonic antigen (CEA).
  • Examination of tissues from carcinomas, adenomas, and metaplastic polyps.

Main Results:

  • Transitional mucosa with altered sialomucin and sulfomucin content was observed in 96% of carcinomas, 50% of adenomas, and 33% of metaplastic polyps.

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  • These transitional changes were present in all small carcinomas (<1 cm).
  • Altered mucin secretion preceded carcinoembryonic antigen (CEA) expression in adjacent mucosa.

    • Conclusions:

    • Transitional mucosal changes adjacent to colorectal disease are likely secondary phenomena, not precancerous.
    • Mucous secretion alterations precede CEA expression in mucosa near colorectal carcinoma.