Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Microenvironments

Microenvironments

Microorganisms inhabit highly localized spaces known as microenvironments, which are defined by distinct physical and chemical characteristics. These include oxygen concentration, pH, temperature, light availability, and nutrient levels. The conditions within a microenvironment can differ markedly from those in the surrounding area and significantly influence microbial growth, metabolism, and community structure.Microenvironments often display sharp physicochemical gradients over small spatial...

Microbial Interactions: Mutualism

Microbial Interactions: Mutualism

Mutualism is a symbiotic interaction in which all participating organisms benefit. These relationships can be obligate or facultative and are fundamental to ecosystem functions across diverse biological systems.Plant–Fungi MutualismOne well-known example is the association between plant roots and mycorrhizal fungi, such as Rhizophagus species. The fungal hyphae penetrate the root hairs and the epidermis, forming an extensive hyphal network that establishes a symbiotic association. Through this...

Microbial Interactions: Cooperation

Microbial Interactions: Cooperation

Microbial cooperation involves beneficial interactions in which different species work together for individual or mutual advantage. These interactions can profoundly influence ecological dynamics and evolutionary processes, and they are essential to many pathogenic and symbiotic relationships.Nematode–Bacteria CooperationA striking example is the relationship between the Gram-negative bacterium Xenorhabdus nematophila and the parasitic nematode Steinernema carpocapsae. Juvenile nematodes...

Microbial Interactions: Competition

Microbial Interactions: Competition

Microbial competition is an ecological interaction in which microorganisms vie for limited resources within shared environments. These resources may include nutrients, space, or light, depending on the system. The intensity and outcome of competition are influenced by the environmental context, such as nutrient availability, spatial constraints, and the diversity of microbial species present. These competitive interactions significantly influence the structure, function, and resilience of...

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

The Tumor Microenvironment

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

SMARCA4 loss reprograms p300 chromatin occupancy to subvert p53-mediated transcriptional repression in ovarian small cell carcinoma.

Nature communications·2026

Same author

Distinct immune landscapes characterize highly versus minimally invasive brain metastases.

JCI insight·2026

Same author

Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergetics.

eLife·2026

Same author

The integrated stress response in cancer: mechanisms of tumor adaptation and therapeutic targeting.

Biochemical Society transactions·2026

Same author

ATR and PKMYT1 Inhibition Resensitizes a Subset of TNBC Patient-Derived Models to Carboplatin, Inducing Mitotic Catastrophe.

Cancer research communications·2026

Same author

SMARCA4/2 loss reduces BCL-xL expression and confers a druggable MCL1 dependency in cancer.

NPJ precision oncology·2026

Search research articles

Related Experiment Video

Updated: May 13, 2026

Using Microarrays to Interrogate Microenvironmental Impact on Cellular Phenotypes in Cancer

Using Microarrays to Interrogate Microenvironmental Impact on Cellular Phenotypes in Cancer

Published on: May 21, 2019

It takes two to tango in the microenvironment!

Josie Ursini-Siegel, Morag Park

Breast Cancer Research : BCR

|March 21, 2013

Summary

This summary is machine-generated.

An epithelial stress response in breast cells reprograms nearby fibroblasts, promoting tumor-like changes. These reciprocal interactions between epithelial and stromal cells drive early breast cancer progression.

More Related Videos

Fabrication of a Multiplexed Artificial Cellular MicroEnvironment Array

Fabrication of a Multiplexed Artificial Cellular MicroEnvironment Array

Published on: September 7, 2018

Using Coculture to Detect Chemically Mediated Interspecies Interactions

Using Coculture to Detect Chemically Mediated Interspecies Interactions

Published on: October 31, 2013

Related Experiment Videos

Last Updated: May 13, 2026

Using Microarrays to Interrogate Microenvironmental Impact on Cellular Phenotypes in Cancer

Using Microarrays to Interrogate Microenvironmental Impact on Cellular Phenotypes in Cancer

Published on: May 21, 2019

Fabrication of a Multiplexed Artificial Cellular MicroEnvironment Array

Fabrication of a Multiplexed Artificial Cellular MicroEnvironment Array

Published on: September 7, 2018

Using Coculture to Detect Chemically Mediated Interspecies Interactions

Using Coculture to Detect Chemically Mediated Interspecies Interactions

Published on: October 31, 2013

Area of Science:

Cell Biology
Cancer Research
Oncology

Background:

Investigates the role of epithelial stress responses in mammary tumorigenesis.
Examines the interaction between human mammary epithelial cells and fibroblasts.

Discussion:

Epithelial stress induces pro-tumorigenic fibroblast reprogramming via activin A or prostaglandin E2.
Reprogrammed fibroblasts enhance epithelial cell migration.
In vitro findings mirror early breast cancer lesions (ductal carcinoma in situ) with activated stroma.

Key Insights:

Reciprocal epithelial-stromal interactions are crucial for early breast cancer progression.
Fibroblast activation is driven by epithelial-derived factors like activin A and prostaglandin E2.
Hallmarks of activated stroma, including immune and endothelial cell infiltration, are present even in pre-malignant lesions.

Outlook:

Further research into epithelial-stromal crosstalk mechanisms.
Potential therapeutic targets for early breast cancer intervention.
Understanding the role of specific signaling molecules in tumorigenesis.