Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin, heparin),...
Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exclusion of Disperse Orange 3 From the Textile Dye Mix Present in the Baseline Patch-Test Series: A Study by the International Contact Dermatitis Research Group.

Dermatitis : contact, atopic, occupational, drug·2025
Same author

Challenges and real-world solutions for adoption of holistic skincare routine (cleansing, treatment, moisturization, and photoprotection) in acne, rosacea, atopic dermatitis, and sensitive skin: An expert consensus.

Journal of cosmetic dermatology·2024
Same author

Cyanoacrylate contact allergy: Tape stripping modification of conventional patch testing.

Contact dermatitis·2024
Same author

Irritant hand dermatitis to alcohol hand sanitisers in healthcare workers: Possible role of alcohol metabolism polymorphisms.

Contact dermatitis·2023
Same author

Allergic contact dermatitis to multiple salicylates: A case report.

Contact dermatitis·2023
Same author

Co-sensitisation to rubber accelerators and surfactants in three healthcare workers.

Contact dermatitis·2023
Same journal

From Music to Eczema: Dermatitis Caused by Para-Phenylenediamine in a Violinist.

Contact dermatitis·2026
Same journal

Reply to: Acrylate Copolymers/Crosspolymers in Sunscreens: Minimally Allergenic, Without Evidence of Need for Avoidance by (Meth)acrylate-Sensitized Individuals.

Contact dermatitis·2026
Same journal

Contact Allergy and Allergic Contact Dermatitis From Propylene Glycol and Related Glycols: Cosmetic Skin Sensitisers After All?

Contact dermatitis·2026
Same journal

Acrylate Copolymers/Crosspolymers in Sunscreens: Minimally Allergenic, Without Evidence of Need for Avoidance by (Meth)Acrylate-Sensitized Individuals.

Contact dermatitis·2026
Same journal

AI-Assisted Automated Two-Stage Patch Test Interpretation System Using Vision Transformer.

Contact dermatitis·2026
Same journal

Use of Tralokinumab in a Hairdresser With Severe Chronic Hand Eczema and Occupational Allergic Contact Dermatitis.

Contact dermatitis·2026
See all related articles

Related Experiment Video

Updated: May 13, 2026

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

Chemical atopy.

Pailin Puangpet1, Joey Lai-Cheong, John P McFadden

  • 1Department of Cutaneous Allergy, St. John's Institute of Dermatology, St. Thomas' Hospital, London, SE1 7EH, UK. pailin.samutrapong@gmail.com

Contact Dermatitis
|March 21, 2013
PubMed
Summary
This summary is machine-generated.

Chemical exposure can reactivate atopic dermatitis in adults with a history of the condition. This study observed exacerbation following occupational or cosmetic chemical contact, even with negative patch tests.

More Related Videos

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
08:25

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
06:47

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Published on: September 27, 2017

Related Experiment Videos

Last Updated: May 13, 2026

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
10:22

Humanized Mediator Release Assay as a Read-Out for Allergen Potency

Published on: June 29, 2021

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
08:25

Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis

Published on: September 26, 2022

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
06:47

Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment

Published on: September 27, 2017

Area of Science:

  • Dermatology
  • Immunology
  • Toxicology

Background:

  • Atopic disease is linked to protein allergy, but its connection to chemical exposure (haptens, irritants) is less understood.
  • The 'hapten-atopy' hypothesis suggests early-life chemical exposure influences atopy development.
  • Animal models and human studies show links between chemical exposure and atopic conditions.

Purpose of the Study:

  • To investigate the relationship between personal chemical exposure and atopic disease.
  • To examine how chemical exposure affects individuals with a predisposition to atopy.

Main Methods:

  • Case series reporting on patients experiencing atopic dermatitis exacerbation.
  • Observation of exacerbation following repeated cutaneous chemical exposure.

Main Results:

  • Most patients had resolved childhood atopic dermatitis.
  • Repeated chemical exposure (occupational or cosmetic) led to clear atopic dermatitis exacerbation.
  • Patch tests were negative in most cases.

Conclusions:

  • Repeated chemical exposure can occasionally reactivate atopic dermatitis in susceptible individuals.
  • Suggests a mechanism beyond typical allergic reactions for atopic dermatitis flare-ups.